Clinical and metabolic effects of delta 1-dehydro-9-alpha-fluoro hydrocortisone acetate.

The discovery of the therapeutic properties of certain steroids has recently given rise to interesting chemical and pharmacological problems. The remarkable antiphlogistic activities of halogenated derivatives of hydrocortisone, and the disappearance of secondary effects obtained by the A1-diene derivatives of cortisone, have suggested the synthesis of a steroid which joins the two chemical characteristics (Hirschmann, Miller, Beyler, Sarett, and Tishler, 1955; Stafford, Barnes, Bowman, and Meinzinger, 1955; Fried, Florey, Sabo, Herz, Restivo, Borman, and Singer, 1955; Hogg, Lincoln, Nathan, Hanze, Schneider, Beal, and Korman, 1955). Preliminary experiments have been carried out with the following derivative: Al-dehydro-9-mfluoro hydrocortisone acetate, the structural formula of which is shown in Fig. 1. CH20H I CO